Combination of Ingredients with Multiple Actions

Glucosamine &
Chondroitin

Joint Fluid - Description And Roles

Joint Fluid - Oral Absorption Studies

MSM is an ubiquitous organic sulfur compound with widespread occurrence in nature. MSM is normally found in foods and in tissues of animals and humans. When administered to animals, labeled sulfur from MSM localizes into joints for long time periods, suggesting it is a precursor for Glycosaminoglycans (GAGs), proteoglycans and/or collagen. MSM can be metabolized into methionine by gut microbes (methionine is the major precursor for PAPS, the sulfate donor molecule in human tissues).

MSM is similar in molecular structure to DMSO (dimethyl sulfoxide), but contains one more oxygen atom per molecule, resulting in an odorless, tasteless solid. Because of the interest in DMSO for joint health, MSM was also considered for joint health. Several human clinical studies have now found reductions in joint discomfort, improvements in joint function, and improvements in quality of life at doses starting at 1500 mg daily. When combined with 1500 mg of Glucosamine HCL, 1500 mg MSM daily led to additional joint health benefits over either Glucosamine or MSM alone. Thus, MSM has its own benefits for joint health, and provides additional benefits when combined with Glucosamine.

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