SCIENCE BEHIND INGREDIENTS
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Uniflex®UNIFLEX® IS THE KEY DISTINGUISHING DIFFERENCE BETWEEN MOVE FREE® ADVANCED AND OTHER JOINT CARE SUPPLEMENTS. Understanding Uniflex®
Uniflex® is a patented, synergistic combination of two herbal extracts: Chinese Scullcap root (Scutellaria baicalensis) and Black Catechu bark (Acacia catechu). Both herbs and their extracts have been used individually to promote health for hundreds of years. Combined, they create a fast and powerful antioxidant system that extends beyond quenching of free radicals and oxidative tissue damage. Uniflex® was developed by Unigen Pharmaceuticals, Inc. after their Phytologix™ genomic screening procedure that examined 1230 herbs for effects on expression of Cyclooxygenase-1, Cyclooxygenase-2 and 5-Lipoxygenase enzymes from cells. Uniflex® activity was verified by extensive in vitro testing with purified enzymes, human peripheral blood cells, human cell lines using extracts and purified actives. Uniflex® activity was confirmed in in vivo animal testing after oral administration by air pouch, ear swelling, collagen-induced joint discomfort and formaldehyde-induced joint discomfort models. Uniflex® has been shown to support healthy regulation of gene expression to promote joint health.
Chinese Scullcap (huang qin) has traditional use in China as a cold, bitter tonic herb used for many applications as a single agent and part of a combination of herbs. Modern scientific study has determined multiple health benefits for Chinese Scullcap and its major components: Free B-Ring Flavonoids (mostly baicalin). Baicalin has a molecular structure closely similar to quercetin (a ubiquitous and common flavonoid found in most vegetables, fruits and grains). Chinese Scullcap is also a component of several Kanpo Medicines in the current Japanese health care system. Chinese Scullcap and its flavonoid components have thousands of peer-reviewed publications in the scientific literature. Chinese Scullcap and its components are well-characterized, and show potent biological effects from in vitro, animal and human clinical outcome studies. This database helps explain how those attributes can help support and maintain healthy joint comfort and function. Black Catechu bark has been used for human health in Chinese and Indian health systems for hundreds of years. Black Catechu is a rich source of (+)-catechin, a commonly-occurring flavan (from the bioflavonoid family of phytonutrients), from whence catechin derives its name. Catechins also describe a class of closely-related bioflavonoids under intense study for health benefits (such as EGCG in green tea and epicatechin in cocoa). Usually, catechins are found together in foodstuffs as a group of 4-8 related compounds, but in Black Catechu, catechin itself is predominant. Like baicalin, catechin has a rich legacy of in vitro, animal and human studies in the scientific literature. Importantly, catechin is found in significant amounts in common foods such as green tea, chocolate/cocoa, red wine, grapes, apples and many other fruits and vegetables. Catechin is normally found in plasma/serum of humans eating a mixed diet. Antioxidants and Joint Health
Chinese Scullcap flavonoids and catechin exhibit potent antioxidant properties. Uniflex® itself has shown potent antixodant activity equivalent to pr greater than other pure antioxidants by the ORAC test (see Table below). Both Chinese Scullcap flavonoids and catechin have documented absorption and uptake into tissues in animals and humans, unlike other flavonoids, meaning their antioxidant activity has potential for biological effects. Joint health is dependent on healthy antioxidant status. Free radical attack and oxidative damage can cause physical damage on a molecular level to joint tissue components, initiating a cascade of degradation and inappropriate cytokine release. Also, free radical attack and oxidative damage triggers events in cells that undermine maintenance of healthy tissue upkeep. At the least, free radical attack and oxidative damage can contribute to loss of joint structures and functions during the aging process. Research has shown that additional antioxidants in the diet are associated with better joint health. Ingesting antioxidants with known absorption, tissue uptake, metabolism and potent biological actions is a logical way to support joint health.
Uniflex® antioxidant system protects cartilage and joint tissue:
References
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THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION.
THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE. |
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